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PolyLC INC ionexchange column
Ionexchange Column, supplied by PolyLC INC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ionexchange+column/ionexchange+column/pm40540249-47-2-8
Average 90 stars, based on 1 article reviews
ionexchange column - by Bioz Stars, 2026-10
90/100 stars

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Article Title: Native Top-Down Proteomics of Endogenous Protein Complexes Enabled by Online Two-Dimensional Liquid Chromatography.
Article Snippet: Protein complexes are essential for virtually all biological processes, yet their structural characterization remains a major challenge due to their heterogeneous, dynamic nature and the complexity of the proteome.. Native top-down mass spectrometry (nTDMS) has emerged as a powerful tool for comprehensive structural characterization of purified protein complexes, but its application to endogenous protein complexes in the proteome is challenging and typically requires labor-intensive and timeconsuming prefractionation.. Here, for the first time, we develop a nondenaturing online two-dimensional liquid chromatography (2D-LC) method for native top-down proteomics (nTDP), enabling highthroughput structural analysis of endogenous protein complexes.



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